Someone used an Nvidia and AMD GPU at the same time. Here’s …

An AMD RX 6600 and Nvidia RTX 4090 being used together in the same setup.

Well, now we have seen it all. You may have heard of dual GPU setups in the past, but combining AMD and Nvidia in the same system? Even if you are using two of the best graphics cards, this will always be difficult. However, it’s now been done and benchmarked, and the results are surprisingly good – with a few major caveats.

Quasarzone took a chance on this, as the outlet itself admits, “crazy idea,” and it turned out better than most of us expected. The publication paired the Nvidia RTX 4090 with the RX 6600 to attempt to use both GPUs simultaneously. The goal was not just to see if it was possible to make it work, but to try the combined power of Nvidia’s DLSS3 and AMD’s Fluid Motion Frames (AFMF). The latter is still in the technical preview stage.

As expected, running such a combo of GPUs is no easy feat, so the setup process seems quite daunting. After installing the RTX 4090 and RX 6600 in the test system (which also included an AMD Ryzen 9 7950X3D), the tester had to install drivers for both GPUs, including the beta driver for AMD cards, in order to access AFMF. The RX 6600 was set as the primary GPU, while the RTX 4090 took on the rendering role. In this scenario, the AMD card controls the display output, and the Nvidia GPU renders the game.

It’s worth noting that DLSS 3 and AFMF work differently. Nvidia’s DLSS 3 increases frame rates by interleaving generated images between rendered frames. It is only available on RTX 40 GPUs and needs to be supported by the game to work. On the other hand, AFMF is enabled on the driver side, which means it should work with all DX11 and DX12 games. Setting up the GPU this way allowed games to first go through Nvidia’s DLSS3 and then hit AMD’s Fluid Motion Frames before reaching the display.

RTX 4090.
Jacob Roach/

Now, for the juicy parts – QuasarZone was able to achieve huge increases in frames per second (FPS) in some of the most demanding games, including cyberpunk 2077, Call of Duty: Modern Warfare III, Ratchet & Clank: Rift Apart, And Starfield, Starfield DLSS doesn’t even support frame generation yet, so it’s not included in the results.

QuasarZone was able to almost triple the original performance cyberpunk 2077, reaching 209 fps with both DLSS frame generation and AFMF enabled. This is an increase of 291% compared to native FPS. Similar gains can be seen in all other titles, which is an impressive performance for two GPUs that should never have ended up in the same PC.

Does this mean that this will be the new dream setup for enthusiasts, something like Dual Titan GPUs have been in the past? no chance. Connecting two GPUs from different vendors, with drivers, is not sustainable and can lead to major instability, crashes, blue screens and what have you. It was a fun experiment, and clearly, it worked, but it probably won’t work for very long.

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